Cowboys vs. Bills prediction, odds, spread, injuries, trends for NFL Week 15

A full betting preview for the Dallas Cowboys' Week 15 matchup against the Buffalo Bills.

Dec 10, 2023; Arlington, Texas, USA; Dallas Cowboys quarterback Dak Prescott (4) throws a pass
Dec 10, 2023; Arlington, Texas, USA; Dallas Cowboys quarterback Dak Prescott (4) throws a pass / Tim Heitman-USA TODAY Sports
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Don't look now, but the Dallas Cowboys are in first place in the NFC East and are the No. 2 seed in the NFC. Behind five straight wins, including one last week against the Eagles, the Cowboys control its destiny to the division crown.

Dallas will put their winning streak on the line against Josh Allen on the Buffalo Bills on Sunday. The Bills are coming off of a must-win against the Chiefs last week to keep themselves in the playoff hunt in the AFC.

The Bills are shockingly two-point favorites at home against the Cowboys, who are only 3-3 away from AT&T Stadium this season. Can the Cowboys prove to the NFL world that they can win on the road against good teams?

Below, we will break down this Week 15 matchup and give our best bet!

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Cowboys vs. Bills Odds, Spread and Total

Cowboys vs. Bills Betting Trends

  • The Cowboys are 3-3 ATS on the road this season
  • The OVER is 5-2 in Dallas’ last seven games
  • Buffalo is 2-7 ATS in its last nine games
  • The UNDER is 5-0 in the Bills’ last five home games

Cowboys vs. Bills Injury Reports

Cowboys Injury Report

  • Jonathan Hankins - DT - Questionable

Bills Injury Report

  • Dalton Kincaid - TE - Questionable
  • Micah Hyde - S - Questionable
  • AJ Epenesa - DE - Questionable

Cowboys vs. Bills How to Watch

  • Date: Sunday, Dec. 17
  • Game Time: 4:25 p.m. EST
  • Venue: Highmark Stadium
  • How to Watch (TV): FOX
  • Cowboys Record: 10-3
  • Bills Record: 7-6

Cowboys vs. Bills Key Players to Watch

Dallas Cowboys

Dak Prescott: After leading the Cowboys to a 20-point win over the Eagles last week, Prescott is now the frontrunner to win MVP. This season, the quarterback is completing 69.3% of his passes for 3,505 yards, 28 touchdowns and six interceptions. He’s playing at a high level and has Cowboys fans believing this could be the year they make a deep run in the playoffs.

Buffalo Bills

Stefon Diggs: For the Bills to upset the Cowboys on Sunday, they need to find a way to get Diggs going in the passing game. Last week against the Chiefs, the star wide receiver had four receptions (11 targets) for 24 yards. 

Diggs is only averaging 39.7 yards per game in their last four games. His best game within that period came against the Eagles, where he recorded six receptions (11 targets) for 74 yards and a touchdown. The 30-year-old has a tough matchup on Sunday as the Cowboys’ defense has a talented cornerback duo with DaRon Bland and Stephon Gilmore.

Cowboys vs. Bills Prediction and Pick

The last time we saw the Cowboys on the road, they defeated the Panthers 33-10 in Week 11. However, the last time Dallas played a team with a winning record on the road was the Eagles in Week 9, where the Cowboys lost by three points.

The Cowboys will have a tough matchup as the Bills are coming off a hard-fought win over the Chiefs. Buffalo is fighting for its playoff life and needs every win it can get.

The Bills have played well at home this season (5-2) and are 3-3 against the spread as a home favorite. The only two losses they suffered at home were against the Broncos (24-22) and the Jaguars (25-20). In both games, Allen threw an interception. He must be careful with his passes on Sunday as the Cowboys CB DaRon Bland leads the league in interceptions (8).

As for the Cowboys, Prescott needs to continue what he’s doing and get everyone involved in the offense. 

This season, the veteran quarterback is completing 63.5% of his passes for 1,380 yards, eight touchdowns, and four interceptions. It’s a stark contrast from what Prescott has done at home (71.3%, 23 TDs, 2 INTs), so we will see if that trend continues in cold Buffalo on Sunday. 

In regards to a pick, I’ll lay the points with Dallas. Buffalo had a big win on Sunday, but I wonder if they can carry that momentum into this week’s game against a Cowboys team scoring 40.2 points per game over their last five games.

Game odds refresh periodically and are subject to change.